While the use of Lynparza is limited and approved for a small group of cancer patients, it is a step in the right direction. In this episode, we will focus on a few things you should know about the use of Lynparza.
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Treatment of pancreatic patients using Lynparza depends upon the biology of the patient and the type of tumor.
While treatment of pancreatic cancer using Lynparza has been successful: here are a few things to note about the drug.
One: Lynparza is an oral therapy
While there are various immunotherapy for various cancer types, people suffering from pancreatic cancer take Lynparza at home. Lynparza is a targeted therapy that blocks “certain activities unique to cancer cells – called a PARP inhibitor.”
An article published on Pancreatic Cancer Action Network mentions the following:
“PARP (poly ADP ribose polymerase) is a protein that helps cells repair DNA damage. PARP inhibitors block this process, causing DNA damage to build up.
Patients who have a BRCA or similar mutation may respond well to treatment with a PARP inhibitor like Lynparza, because these mutations already weaken the cells’ ability to fix damaged DNA.”
Two: Lynparza can be used only after a successful platinum-based chemo
Yes, you heard that right! Not all chemotherapies for pancreatic cancer are platinum-based, which is why pancreatic patients should be treated with chemotherapies such as Oxaliplatin.
The Pancreatic Cancer Action Network article mentions:
“Evidence shows that platinum-containing chemotherapy is effective in pancreatic cancer patients with BRCA and similar mutations. Lynparza builds on this, giving some of these patients a new option for maintenance therapy after responding well to chemotherapy.”
Three: Lynparza is the first FDA-approved pancreatic cancer maintenance therapy drug
Lynparza is used as cancer maintenance drug that stops the progression of the tumor.
The Pancreatic Cancer Action Network article mentions:
“Chemotherapy can cause side effects that may make long-term use challenging. So, it is not uncommon for patients who have remained stable on chemotherapy to stop treatment entirely to give their bodies a break.
When a patient’s cancer is stable after a time on chemotherapy, a maintenance therapy may be used in place of chemotherapy or instead of going off treatment entirely…”
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