Researchers at Stanford University have found a sustainable and rapid way to produce a cancer-eliminating compound in the lab. In this episode, we will learn more about the acclaimed cancer-treating drug.
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The acclaimed cancer-fighting drug is naturally found in a single rainforest and can now be produced synthetically in a lab.
The much talked about compound can only be found in a single plant species in the rainforests of Northeastern Australia.
EBC-46 is a rare compound that triggers a response against tumors. Technically called Tigilanol Tiglate, EBC-46 breaks the tumor’s blood vessels and kills cancerous cells.
EBC-46 was initially used on dogs to treat a type of cancer. Encouraged by the result, researchers used the compound on humans in clinical trials.
Producing EBC-46 synthetically was initially thought to be impossible; however, researchers at Stanford University used a rare process to create the rare compound in the lab.
An article published on Stanford News mentions the following:
“Given its complex structure, however, EBC-46 had appeared synthetically inaccessible, meaning no plausible path seemed to exist for producing it practically in a laboratory. However, thanks to a clever process, the Stanford researchers demonstrated for the first time how to chemically transform an abundant, plant-based starting material into EBC-46.”
“’We are very excited to report the first scalable synthesis of EBC-46,’ said Paul Wender, the Francis W. Bergstrom Professor in the School of Humanities and Sciences, professor of chemistry and, by courtesy, of chemical and systems biology at Stanford, and corresponding author of a study describing the results in the journal Nature Chemistry. ‘Being able to make EBC-46 in the lab really opens up tremendous research and clinical opportunities,’” the article further reads.
The rare compound is naturally found in blushwood tree’s pink fruit seeds. Blushwood fruits are consumed by kangaroos; however, they avoid the EBC-46-rich seeds.
The Stanford article mentions:
“Injecting far smaller doses of EBC-46 directly into some solid tumors modifies the cellular signaling by PKC. Specifically, EBC-46 is proposed to activate certain forms of PKC, which in turn influence the activity of various proteins in the cancerous cells, attracting an immune response by the host’s body. The resulting inflammation makes the tumor’s vasculature, or blood vessels, leaky, and this hemorrhaging causes the tumorous growth to die.”
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