This New Treatment Offers Hope to Cancer Patients Running Out of Choices – Part Two
Doctors have discovered that this new cancer treatment has the potential to stop the disease and reverse resistance to immunotherapy.
In the last episode, we explored how the new two-pronged therapy works for cancer patients who have exhausted all treatment options. In this episode, we will learn more about the new cancer treatment that has taken researchers and scientists by surprise.
Pembrolizumab is an immunotherapy drug, which is widely used to train the body’s immune system to target and kill cancerous cells in the body. Oncologists found that when pembrolizumab was combined with guadecitabine, it helped in stopping cancerous cells and also assisted the immune system in working against cancer.
Institute of Cancer Research and Royal Marsden NHS Foundation Trust said that the dual combination of drugs has become an effective weapon of choice for cancer patients who have run out of options.
An article published in The Guardian mentions the following:
“Patients in the trial, from the Royal Marsden and University College London hospital, included those with lung, breast, prostate, and bowel cancer.
‘I think one of the most important things about this trial is that we used multiple different methods to look for changes in the immune system, robustly showing that it was being influenced by the combination treatment,’ the study’s chief investigator, Prof Johann de Bono, said.
De Bono, a professor of experimental cancer medicine at the Institute of Cancer Research and a consultant medical oncologist at the Royal Marsden, added: ‘In the long term we hope that if these effects are confirmed in other patient groups and future studies, guadecitabine and pembrolizumab could help to tackle some of the resistance to immunotherapy we see in too many types of cancer.’”
Dr Anna Minchom, the study lead and a scientist at the Institute of Cancer Research, said: “Immunotherapy has shown amazing promise in cancer care over the last decade, but it doesn’t work well in all cancers and cancers can often become resistant. This combination might be a way to target their cancer even after it has stopped responding to immunotherapy.”
The new treatment has proven beneficial for various types of cancer; however, it has proven highly effective for patients suffering from lung cancer. Various patients who were given a year or less to live found that they lived a cancer-free life after using the two-pronged cancer treatment.
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