An exciting new field that can be used to treat cancer is DNA Nanotechnology. In this episode, we will explore how DNA Nanotechnology can be effectively used to fight cancerous cells.
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Traditional cancer treatments have several side effects that sometimes can prove fatal. However, with DNA Nanotechnology, researchers are a step closer to treating cancer by significantly reducing side effects.
The lack of effective drug delivery systems (DDSs) triggered scientists and researchers to work on various organic and inorganic materials that can effectively be used to treat cancer without any side effects. Recently, scientists have started working on DNA material to construct artificial nanostructures, which are not present in biological systems.
Any article published on the National Library of Medicine mentions the following:
“…DNA, being a genetic material, possesses high biocompatibility and low cytotoxicity ideal for applications in the biomedical field 5,9. Its remarkable molecular recognition properties, and complementary base pairing, along with its stability, mechanical rigidity, nano-dimensions of the repeating unit, easily custom synthesis with manipulative length of strands allow the formation of most every shape of nanostructures…”
DNA origami
DNA origami’s high drug-loading efficiency makes it a superb candidate for turning it into nontoxic drug nanocarriers.
The molecular of DNA is used by DNA nanotechnology to create artificial DNA structures. It can be used in a vast range of applications in fields such as material science, biology, and medicine.
One of several advantages of DNA origami is that it can simultaneously release multiple drugs. Researchers working on various new cancer therapies are working in the field of liposomes. Researchers are trying to discover ways through which various drugs can be loaded in a single liposome.
The National Library of Medicine article mentions:
“DNA nanotechnology could provide an excellent designing tool for the construction of novel drug delivery vehicles possessing optimum biocompatibility along with high cellular uptake kinetics of drug-loaded DNA nanostructures. DNA nanotechnology enables tuning and optimization for their best performance in in vivo and in vitro experiments by judiciously selecting the shape, size and functionalities of DNA nanostructures owing to the shape and size-dependent EPR effect.”
Scientists and researchers are making many new breakthroughs in the field of cancer research. Be it precision oncology or immunotherapy, modern science is rapidly developing treatments that can be used in treating cancer effectively.
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